The Antigenicity Of Clostridium Botulinum Type C Toxin Administered Per Os
Large quantities of toxoid given to rabbits per os did not elicit a primary immune response. Toxin absorbed through the intestinal wall of guinea-pigs and toxoided produced an anamnestic response on injection into basically-immune rabbits, but had no effect on fully susceptible rabbits. By dosing sufficient toxin or toxoid per os to basically-immune rabbits anamnestic responses could be produced.